June 30, 2025
In laboratory environments, achieving accurate fluid transfer is crucial — especially when dealing with small volumes in diagnostic labware and drug delivery devices. However, fluid retention in pipette tips can lead to inconsistencies, wasted reagents, and compromised assay accuracy. To address these challenges, Techmer has introduced a non-PFAS surface modification technology designed to optimize fluid management. We spoke with Laurence Chow, Techmer PM’s Application Development Engineer, who led the development of this technology, to learn more.
Q: Why is fluid retention a growing concern in laboratory settings?
A: Fluid retention in pipette tips and other labware can significantly impact assay accuracy, especially in applications involving small volumes. Even a few microliters of residual liquid can skew results, leading to costly errors. Additionally, in bioprocessing and drug delivery, every drop counts — minimizing fluid loss not only improves accuracy but also reduces waste.
Q: What specific challenges did Techmer set out to address with this non-PFAS technology?
A: We focused on creating a surface modification that would provide low retention without relying on PFAS, which is increasingly restricted due to environmental and health concerns. The objective was to achieve stable surface resistivity, low extractables, and consistent performance across a range of fluids. The solution needed to work seamlessly in both diagnostic and bioprocessing applications.
Q: How does the non-PFAS solution perform compared to traditional fluorinated coatings?
A: Traditional fluorinated coatings are effective in reducing surface tension, but they come with regulatory and environmental drawbacks. Our non-PFAS technology achieves similar — if not better — performance by using specialized additives that reduce surface energy and minimize fluid retention. Contact angle measurements indicate a significant reduction in fluid retention while maintaining mechanical integrity.
Q: What other benefits does the non-PFAS solution offer?
A: Aside from minimizing fluid retention, the non-PFAS technology is engineered for high durability, chemical resistance, and low extractables. This is particularly important in pharmaceutical and diagnostic applications where contamination can compromise results. Additionally, the regulatory landscape is moving toward non-PFAS materials, making this technology a more sustainable, future-proof choice.
Q: How do you see this technology evolving in the future?
A: The initial focus was on diagnostic labware and pipette tips, but we see broader applications in bioprocessing, microfluidics, and even high-throughput screening devices. The potential to customize surface modifications for specific fluid properties opens up opportunities to further reduce waste and improve accuracy across various applications.
For more information about Techmer’s non-PFAS fluid management solutions and how Premix is leveraging similar technologies, contact us today.